Anti-NLRP2 antibody (620-700 aa) (STJ192416)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 620-700
General Information
| Short Description | Rabbit polyclonal anti-NACHT, LRR and PYD domains-containing protein 2 (620-700 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NLRP2 |
| Gene ID | 55655 |
| Uniprot ID | NALP2_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 620-700 |
| Immunogen Region | 620-700 aa |
| Specificity | NALP2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 2Nucleotide-Binding Site Protein 1Pyrin Domain And Nacht Domain-Containing Protein 1Pyrin-Containing Apaf1-Like Protein 2 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 2 antibodyAnti-Nucleotide-Binding Site Protein 1 antibodyAnti-Pyrin Domain And Nacht Domain-Containing Protein 1 antibodyAnti-Pyrin-Containing Apaf1-Like Protein 2 antibodyAnti-NLRP2 antibodyAnti-NALP2 antibodyAnti-NBS1 antibodyAnti-PAN1 antibodyAnti-PYPAF2 antibody |
Information sourced from Uniprot.org