| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NLRP12 (862-1061) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NLRP12 |
| Gene ID: |
91662 |
| Uniprot ID: |
NAL12_HUMAN |
| Immunogen Region: |
862-1061 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 862-1061 of human NLRP12 (NP_653288.1). |
| Immunogen Sequence: |
WLKICRLTAAACDELASTLS VNQSLRELDLSLNELGDLGV LLLCEGLRHPTCKLQTLRLG ICRLGSAACEGLSVVLQANH NLRELDLSFNDLGDWGLWLL AEGLQHPACRLQKLWLDSCG LTAKACENLYFTLGINQTLT DLYLTNNALGDTGVRLLCKR LSHPGCKLRVLWLFGMDLNK MTHSRLAALRVTKPYLDIGC |
| Tissue Specificity | Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes. |
| Function | Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Inhibits also the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation. Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 12Monarch-1Pyrin-Containing Apaf1-Like Protein 7Regulated By Nitric Oxide |
| Database Links | Reactome: R-HSA-9705671 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 12 antibodyAnti-Monarch-1 antibodyAnti-Pyrin-Containing Apaf1-Like Protein 7 antibodyAnti-Regulated By Nitric Oxide antibodyAnti-NLRP12 antibodyAnti-NALP12 antibodyAnti-PYPAF7 antibodyAnti-RNO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
