• STJ73350 (1µg/ml) staining of Mouse Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-Nlrp12-Mouse antibody (Internal) (STJ73350)

SKU:
STJ73350-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Nlrp12-Mouse (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Immunogen Region: Internal
Accession Number: NP_001028603.1
Immunogen Sequence: DDPPEPSGVQTQST
Function Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation. Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue.
Protein Name Nacht - Lrr And Pyd Domains-Containing Protein 12
Monarch-1
Pyrin-Containing Apaf1-Like Protein 7
Pypaf7
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Nacht - Lrr And Pyd Domains-Containing Protein 12 antibody
Anti-Monarch-1 antibody
Anti-Pyrin-Containing Apaf1-Like Protein 7 antibody
Anti-Pypaf7 antibody
Anti-Nlrp12 antibody
Anti-NALP12 antibody

Information sourced from Uniprot.org

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