| Short Description : | Rabbit polyclonal NKX3.1 (1-80) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NKX3-1 |
| Gene ID: | 4824 |
| Uniprot ID: | NKX31_HUMAN |
| Immunogen Region: | 1-80 |
| Immunogen Sequence: | MLRVPEPRPGEAKAEGAAPP TPSKPLTSFLIQDILRDGAQ RQGGRTSSQRQRDPEPEPEP EPEGGRSRAGAQNDQLSTGP |
| Specificity: | Recombinant fusion protein containing a sequence within amino acids 1-80 of human NKX3.1 (NP_006158.2). |
| Tissue Specificity | Highly expressed in the prostate and, at a lower level, in the testis. |
| Post Translational Modifications | Ubiquitinated by TOPORS.monoubiquitinated at several residues and also polyubiquitinated on single residues. |
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGTAG-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
| Protein Name | Homeobox Protein Nkx-3.1Homeobox Protein Nk-3 Homolog A |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-3.1 antibodyAnti-Homeobox Protein Nk-3 Homolog A antibodyAnti-NKX3-1 antibodyAnti-NKX3.1 antibodyAnti-NKX3A antibody |
Information sourced from Uniprot.org
![Anti-NKX3.1 antibody [EP356] (STJ16101453)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/151959/347005/STJ16101453_1__66088.1681999253.jpg?c=1 "Anti-NKX3.1 antibody [EP356] (STJ16101453)")
