| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Homeobox protein Nkx-2.1 (27-76 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NKX2-1 |
| Gene ID: | 7080 |
| Uniprot ID: | NKX21_HUMAN |
| Immunogen Region: | 27-76 aa |
| Specificity: | TTF-1 Polyclonal Antibody detects endogenous levels of TTF-1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TTF-1 at the amino acid range 27-76 |
| Post Translational Modifications | Phosphorylated on serine residues by STK3/MST2. |
| Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. |
| Protein Name | Homeobox Protein Nkx-2.1 Homeobox Protein Nk-2 Homolog A Thyroid Nuclear Factor 1 Thyroid Transcription Factor 1 Ttf-1 Thyroid-Specific Enhancer-Binding Protein T/Ebp |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-2.1 antibody Anti-Homeobox Protein Nk-2 Homolog A antibody Anti-Thyroid Nuclear Factor 1 antibody Anti-Thyroid Transcription Factor 1 antibody Anti-Ttf-1 antibody Anti-Thyroid-Specific Enhancer-Binding Protein antibody Anti-T/Ebp antibody Anti-NKX2-1 antibody Anti-NKX2A antibody Anti-TITF1 antibody Anti-TTF1 antibody |
Information sourced from Uniprot.org