Anti-NKRF antibody (550-630 aa) (STJ190181)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 550-630
General Information
| Short Description | Rabbit polyclonal anti-NF-kappa-B-repressing factor (550-630 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NKRF |
| Gene ID | 55922 |
| Uniprot ID | NKRF_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 550-630 |
| Immunogen Region | 550-630 aa |
| Specificity | NKRF Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. |
| Protein Name | Nf-Kappa-B-Repressing FactorNfkb-Repressing FactorNrfProtein Itba4 |
| Database Links | |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Nf-Kappa-B-Repressing Factor antibodyAnti-Nfkb-Repressing Factor antibodyAnti-Nrf antibodyAnti-Protein Itba4 antibodyAnti-NKRF antibodyAnti-ITBA4 antibodyAnti-NRF antibody |
Information sourced from Uniprot.org