Anti-NKIRAS2 antibody (STJ191911)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-NF-kappa-B inhibitor-interacting Ras-like protein 2 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NKIRAS2 |
| Gene ID | 28511 |
| Uniprot ID | KBRS2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | KBRS2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. |
| Protein Name | Nf-Kappa-B Inhibitor-Interacting Ras-Like Protein 2I-Kappa-B-Interacting Ras-Like Protein 2Kappa B-Ras Protein 2Kappab-Ras2 |
| Database Links | Reactome: R-HSA-1810476Reactome: R-HSA-445989Reactome: R-HSA-933542 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor-Interacting Ras-Like Protein 2 antibodyAnti-I-Kappa-B-Interacting Ras-Like Protein 2 antibodyAnti-Kappa B-Ras Protein 2 antibodyAnti-Kappab-Ras2 antibodyAnti-NKIRAS2 antibodyAnti-KBRAS2 antibody |
Information sourced from Uniprot.org