Anti-NKG2D antibody [CX5] (STJA0027539)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Rat monoclonal Nkg2-D Type Ii Integral Membrane Protein antibody for use in Blocking, ELISA and FC in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | Blocking/ELISA/FC |
| Host | Rat |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | CX5 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4, 0.09% Sodium azide. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | Klrk1 |
| Gene ID | 27007 |
| Uniprot ID | NKG2D_MOUSE |
Additional Info
| Function | Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. |
| Protein Name | Nkg2-D Type Ii Integral Membrane ProteinKiller Cell Lectin-Like Receptor Subfamily K Member 1Nk Cell Receptor DNkg2-D-Activating Nk ReceptorCd Antigen Cd314 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinColocalized With Hcst And Tyrobp On The Cell Surface |
| Alternative Antibody Names | Anti-Nkg2-D Type Ii Integral Membrane Protein antibodyAnti-Killer Cell Lectin-Like Receptor Subfamily K Member 1 antibodyAnti-Nk Cell Receptor D antibodyAnti-Nkg2-D-Activating Nk Receptor antibodyAnti-Cd Antigen Cd314 antibodyAnti-Klrk1 antibodyAnti-Nkg2d antibody |
Information sourced from Uniprot.org