| Host: | Rabbit |
| Applications: | ELISA/WB |
| Reactivity: | Bovine/Human/Monkey/Panda |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-NKG2D (180-230) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.55 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Klrk1 |
| Gene ID: | 24934 |
| Uniprot ID: | NKG2D_RAT |
| Immunogen Region: | 180-230 |
| Immunogen: | Synthetic peptide taken within amino acid region 180-230 on rat NKG2D protein. |
| Tissue Specificity | Expressed by natural killer cells and by resting thoracic duct CD4+ and CD8+ T-cells, but not by thymocytes or other hemopoietic cells. Expressed by DC cells. |
| Function | Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins. |
| Protein Name | Nkg2-D Type Ii Integral Membrane Protein Killer Cell Lectin-Like Receptor Subfamily K Member 1 Nk Cell Receptor D Nk Lectin-Like Receptor Nkllr Nkg2-D-Activating Nk Receptor Nkr-P2 Cd Antigen Cd314 |
| Database Links | Reactome: R-RNO-198933 Reactome: -RNO-2424491 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein Colocalized With Hcst On The Cell Surface |
| Alternative Antibody Names | Anti-Nkg2-D Type Ii Integral Membrane Protein antibody Anti-Killer Cell Lectin-Like Receptor Subfamily K Member 1 antibody Anti-Nk Cell Receptor D antibody Anti-Nk Lectin-Like Receptor antibody Anti-Nkllr antibody Anti-Nkg2-D-Activating Nk Receptor antibody Anti-Nkr-P2 antibody Anti-Cd Antigen Cd314 antibody Anti-Klrk1 antibody Anti-Nkg2d antibody Anti-Nkrp2 antibody |
Information sourced from Uniprot.org