Anti-NKD2 antibody (Internal) (STJ71369)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NKD2 (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave bands at approx 80kDa, 38kDa and 26kDa in Mouse Brain lysates after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NKD2 |
| Gene ID | 85409 |
| Uniprot ID | NKD2_HUMAN |
| Accession Number | NP_149111.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | HKRYRQKGREGHS |
Additional Info
| Post Translational Modifications | Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25. |
| Function | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. |
| Protein Name | Protein Naked Cuticle Homolog 2Naked-2Hnkd2 |
| Cellular Localisation | Cell MembraneCytoplasmCytoplasmic Vesicle |
| Alternative Antibody Names | Anti-Protein Naked Cuticle Homolog 2 antibodyAnti-Naked-2 antibodyAnti-Hnkd2 antibodyAnti-NKD2 antibody |
Information sourced from Uniprot.org