Anti-NIT1 antibody [R09-9D7] (STJA0034642)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human NIT1
General Information
| Short Description | Rabbit monoclonal anti-NIT1 for use in WB and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-9D7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | NIT1 |
| Gene ID | 4817 |
| Uniprot ID | NIT1_HUMAN |
| Immunogen | A synthetic peptide of human NIT1 |
Additional Info
| Tissue Specificity | Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. |
| Function | Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells.this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. |
| Protein Name | Deaminated Glutathione AmidaseDgsh AmidaseNitrilase Homolog 1 |
| Database Links | |
| Cellular Localisation | Isoform 2: MitochondrionIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Deaminated Glutathione Amidase antibodyAnti-Dgsh Amidase antibodyAnti-Nitrilase Homolog 1 antibodyAnti-NIT1 antibody |
Information sourced from Uniprot.org