Anti-NHERF antibody [EBP-10] (STJ16100695)

SKU:
STJ16100695-01

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Host: Mouse
Applications: IP/WB/IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-NHERF is suitable for use in Immunoprecipitation, Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: EBP-10
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration: 1 mg/mL
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: NHERF1
Gene ID: 9368
Uniprot ID: NHRF1_HUMAN
Immunogen: Bacterially produced recombinant full-length human NHERF1.
Tissue Specificity Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast.
Post Translational Modifications Phosphorylated on serine residues.
Function Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
Protein Name Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf1
Nherf-1
Ezrin-Radixin-Moesin-Binding Phosphoprotein 50
Ebp50
Regulatory Cofactor Of Na(+/H(+ Exchanger
Sodium-Hydrogen Exchanger Regulatory Factor 1
Solute Carrier Family 9 Isoform A3 Regulatory Factor 1
Cellular Localisation Cytoplasm
Apical Cell Membrane
Endomembrane System
Peripheral Membrane Protein
Cell Projection
Filopodium
Ruffle
Microvillus
Translocates From The Cytoplasm To The Apical Cell Membrane In A Podxl-Dependent Manner
Colocalizes With Cftr At The Midpiece Of Sperm Tail
Colocalizes With Actin In Microvilli-Rich Apical Regions Of The Syncytiotrophoblast
Found In Microvilli
Ruffling Membrane And Filopodia Of Hela Cells
Present In Lipid Rafts Of T-Cells
Alternative Antibody Names Anti-Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf1 antibody
Anti-Nherf-1 antibody
Anti-Ezrin-Radixin-Moesin-Binding Phosphoprotein 50 antibody
Anti-Ebp50 antibody
Anti-Regulatory Cofactor Of Na(+/H(+ Exchanger antibody
Anti-Sodium-Hydrogen Exchanger Regulatory Factor 1 antibody
Anti-Solute Carrier Family 9 Isoform A3 Regulatory Factor 1 antibody
Anti-NHERF1 antibody
Anti-NHERF antibody
Anti-SLC9A3R1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance