Anti-NgR3 antibody [SRM13123] (STJ11107853)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal Reticulon-4 Receptor-Like 1 antibody for use in WB, IF, ICC, IF-P, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/IF-P/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM13123 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB, 1:500-1:1000IF/ICC, 1:50-1:200IF-P, 1:50-1:200IHC-P, 1:50-1:200ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RTN4RL1 |
| Gene ID | 146760 |
| Uniprot ID | R4RL1_HUMAN |
| Immunogen | Synthetic peptide. This information is considered to be commercially sensitive. |
| Immunogen Sequence | Human |
Additional Info
| Function | Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. |
| Protein Name | Reticulon-4 Receptor-Like 1Nogo Receptor-Like 2Nogo-66 Receptor Homolog 2Nogo-66 Receptor-Related Protein 3Ngr3 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftPerikaryonCell ProjectionLocalized To The Surface Of NeuronsIncluding Axons |
| Alternative Antibody Names | Anti-Reticulon-4 Receptor-Like 1 antibodyAnti-Nogo Receptor-Like 2 antibodyAnti-Nogo-66 Receptor Homolog 2 antibodyAnti-Nogo-66 Receptor-Related Protein 3 antibodyAnti-Ngr3 antibodyAnti-RTN4RL1 antibodyAnti-NGRH2 antibodyAnti-NGRL2 antibody |
Information sourced from Uniprot.org