| Host: |
NZ White Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat/Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Nz White Rabbit polyclonal antibody anti-NGF is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Shipped as lyophilised. Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Purification: |
Affinity purified |
| Dilution Range: |
Use at a concentration of 1-5 µg/ml. The optimal working concentration should be determined by the end user. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Ngf |
| Gene ID: |
18049 |
| Uniprot ID: |
NGF_MOUSE |
| Specificity: |
Specific for NGF |
| Immunogen: |
Native beta-nerve growth factor (Ngfb, beta-NGF) purified from mouse submandibular gland |
| Function | Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form. |
| Protein Name | Beta-Nerve Growth FactorBeta-Ngf |
| Database Links | Reactome: R-MMU-167060Reactome: -MMU-170968Reactome: -MMU-170984Reactome: -MMU-177504Reactome: -MMU-187042Reactome: -MMU-198203Reactome: -MMU-205017Reactome: -MMU-205025Reactome: -MMU-205043Reactome: -MMU-209543Reactome: -MMU-209560Reactome: -MMU-209563 |
| Cellular Localisation | SecretedEndosome LumenProngf Is Endocytosed After Binding To The Cell Surface Receptor Formed By Sort1 And Ngfr |
| Alternative Antibody Names | Anti-Beta-Nerve Growth Factor antibodyAnti-Beta-Ngf antibodyAnti-Ngf antibodyAnti-Ngfb antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
