| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NGDN (61-209) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NGDN |
| Gene ID: |
25983 |
| Uniprot ID: |
NGDN_HUMAN |
| Immunogen Region: |
61-209 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 61-209 of human NGDN (NP_001036100.1). |
| Immunogen Sequence: |
LMYLMDLTHLILDKASGGSL QGHDAVLRLVEIRTVLEKLR PLDQKLKYQIDKLIKTAVTG SLSENDPLRFKPHPSNMMSK LSSEDEEEDEAEDDQSEASG KKSVKGVSKKYVPPRLVPVH YDETEAEREKKRLERAKRRA LSSSVIREL |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1*. Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner. |
| Protein Name | NeuroguidinCentromere Accumulated Nuclear Protein 1Canu1Eif4e-Binding Protein |
| Cellular Localisation | NucleusNucleolusChromosomeCentromereCytoplasmCell ProjectionAxonDendriteFilopodiumTranslocated From Nucleolus To Nuclear Foci In Response To Uv DamageDetected In AxonsDendrites And FilopodiaColocalized With Eif4e In Neurites |
| Alternative Antibody Names | Anti-Neuroguidin antibodyAnti-Centromere Accumulated Nuclear Protein 1 antibodyAnti-Canu1 antibodyAnti-Eif4e-Binding Protein antibodyAnti-NGDN antibodyAnti-C14orf120 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
