Anti-NGDN antibody (61-209) (STJ116757)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NGDN (61-209) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NGDN |
| Gene ID | 25983 |
| Uniprot ID | NGDN_HUMAN |
| Immunogen Region | 61-209 |
| Immunogen Sequence | LMYLMDLTHLILDKASGGSL QGHDAVLRLVEIRTVLEKLR PLDQKLKYQIDKLIKTAVTG SLSENDPLRFKPHPSNMMSK LSSEDEEEDEAEDDQSEASG KKSVKGVSKKYVPPRLVPVH YDETEAEREKKRLERAKRRA LSSSVIREL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 61-209 of human NGDN (NP_001036100.1). |
Additional Info
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1*. Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner. |
| Protein Name | NeuroguidinCentromere Accumulated Nuclear Protein 1Canu1Eif4e-Binding Protein |
| Database Links | |
| Cellular Localisation | NucleusNucleolusChromosomeCentromereCytoplasmCell ProjectionAxonDendriteFilopodiumTranslocated From Nucleolus To Nuclear Foci In Response To Uv DamageDetected In AxonsDendrites And FilopodiaColocalized With Eif4e In Neurites |
| Alternative Antibody Names | Anti-Neuroguidin antibodyAnti-Centromere Accumulated Nuclear Protein 1 antibodyAnti-Canu1 antibodyAnti-Eif4e-Binding Protein antibodyAnti-NGDN antibodyAnti-C14orf120 antibody |
Information sourced from Uniprot.org