Anti-NFKBIZ antibody (STJA0007078)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NFKBIZ
General Information
| Short Description | Rabbit polyclonal anti-NF-kappa-B inhibitor zeta for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NFKBIZ |
| Gene ID | 64332 |
| Uniprot ID | IKBZ_HUMAN |
| Immunogen | Synthesized peptide derived from human NFKBIZ |
| Specificity | This antibody detects endogenous levels of NFKBIZ at Human, Mouse |
Additional Info
| Function | Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). |
| Protein Name | Nf-Kappa-B Inhibitor ZetaI-Kappa-B-ZetaIkb-ZetaIkappabzetaIl-1 Inducible Nuclear Ankyrin-Repeat ProteinInapMolecule Possessing Ankyrin Repeats Induced By LipopolysaccharideMail |
| Database Links | |
| Cellular Localisation | NucleusAggregated In Dot-Like StructuresColocalizes With Ncor2 |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor Zeta antibodyAnti-I-Kappa-B-Zeta antibodyAnti-Ikb-Zeta antibodyAnti-Ikappabzeta antibodyAnti-Il-1 Inducible Nuclear Ankyrin-Repeat Protein antibodyAnti-Inap antibodyAnti-Molecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide antibodyAnti-Mail antibodyAnti-NFKBIZ antibodyAnti-IKBZ antibodyAnti-INAP antibodyAnti-MAIL antibody |
Information sourced from Uniprot.org