Anti-NFIL3 antibody (C-Term) (STJ70077)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NFIL3 (C-Term) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Applications | Pep-ELISA/WB/FC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx. 60kDa band observed in nuclear lysates of cell line Jurkat and HeLa (calculated MW of 51.5kDa according to NP_005375.2). This molecular weight is routinely observed by other sou |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NFIL3 |
| Gene ID | 4783 |
| Uniprot ID | NFIL3_HUMAN |
| Accession Number | NP_005375.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | RLIATQPISASDSG |
Additional Info
| Function | Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-GATTACTGTAACT-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death. Represses the transcription of CYP2A5. Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2. Required for the development of natural killer cell precursors. |
| Protein Name | Nuclear Factor Interleukin-3-Regulated ProteinE4 Promoter-Binding Protein 4Interleukin-3 Promoter Transcriptional ActivatorInterleukin-3-Binding Protein 1Transcriptional Activator Nf-Il3a |
| Database Links | Reactome: R-HSA-400253 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Factor Interleukin-3-Regulated Protein antibodyAnti-E4 Promoter-Binding Protein 4 antibodyAnti-Interleukin-3 Promoter Transcriptional Activator antibodyAnti-Interleukin-3-Binding Protein 1 antibodyAnti-Transcriptional Activator Nf-Il3a antibodyAnti-NFIL3 antibodyAnti-E4BP4 antibodyAnti-IL3BP1 antibody |
Information sourced from Uniprot.org