Anti-Neutrophil Elastase antibody (167-267) [S9MR] (STJ11103639)

Name: Anti-Neutrophil Elastase antibody (167-267) [S9MR] (STJ11103639)
SKU: STJ11103639
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103639

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Short Description	Rabbit monoclonal Neutrophil Elastase (ELANE) (167-267) antibody for use in WB, IHC-P, IF, ICC, IP and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/IP/ELISA
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S9MR
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your speci
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	ELANE
Gene ID	1991
Uniprot ID	ELNE_HUMAN
Immunogen Region	167-267
Immunogen Sequence	SVLQELNVTVVTSLCRRSNV CTLVRGRQAGVCFGDSGSPL VCNGLIHGIASFVRGGCASG LYPDAFAPVAQFVNWIDSII QRSEDNPCPHPRDPDPASRT H
Specificity	A synthetic peptide corresponding to a sequence within amino acids 167-267 of human Neutrophil Elastase (ELANE) (P08246).

Tissue Specificity	Bone marrow cells. Neutrophil.
Function	Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI). Capable of killing E.coli but not S.aureus in vitro.digests outer membrane protein A (ompA) in E.coli and K.pneumoniae.
Protein Name	Neutrophil Elastase Bone Marrow Serine Protease Elastase-2 Human Leukocyte Elastase Hle Medullasin Pmn Elastase
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-1592389 Reactome: R-HSA-5620971 Reactome: R-HSA-6798695 Reactome: R-HSA-6803157 Reactome: R-HSA-977606 Reactome: R-HSA-9911233
Cellular Localisation	Cytoplasmic Vesicle Phagosome Localized In Phagolysosomes Following Ingestion Of E Coli By Neutrophils
Alternative Antibody Names	Anti-Neutrophil Elastase antibody Anti-Bone Marrow Serine Protease antibody Anti-Elastase-2 antibody Anti-Human Leukocyte Elastase antibody Anti-Hle antibody Anti-Medullasin antibody Anti-Pmn Elastase antibody Anti-ELANE antibody Anti-ELA2 antibody

Information sourced from Uniprot.org