Anti-Neurogranin precursor antibody (Internal) (STJ72056)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Neurogranin precursor (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 16kDa band observed in Human Brain (Frontal Cortex) lysate (calculated MW of 7.6kDa according to NP_006167.1). The observed molecular weights correspond to earlier findings in li |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NRGN |
| Gene ID | 4900 |
| Uniprot ID | NEUG_HUMAN |
| Accession Number | NP_006167.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | KIKSGERGRKG |
| Specificity | Reported variants represent identical protein: NP_006167.1, NP_001119653.1 |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. |
| Function | Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. |
| Protein Name | NeurograninNgRc3 Cleaved Into - Neug(55-78 |
| Database Links | Reactome: R-HSA-9620244 |
| Alternative Antibody Names | Anti-Neurogranin antibodyAnti-Ng antibodyAnti-Rc3 Cleaved Into - Neug(55-78 antibodyAnti-NRGN antibody |
Information sourced from Uniprot.org