||WB, IHC, IF, IP
||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit monoclonal antibody anti-Neurofilament L is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation.
||PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
||WB 1:500-1:2000IHC 1:50-1:200IF 1:50-1:200IP 1:50-1:200
||Store in a freezer at-20°C and avoid freeze-thaw cycles.
||Recombinant protein of human Neurofilament L.
| Post Translational Modifications || O-glycosylated. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. Ubiquitinated in the presence of TRIM2 and UBE2D1. |
| Function || Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. |
| Protein Name || Neurofilament Light PolypeptideNf-L68 Kda Neurofilament ProteinNeurofilament Triplet L Protein |
| Database Links || Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation || Cell ProjectionAxonCytoplasmCytoskeleton |
| Alternative Antibody Names || Anti-Neurofilament Light Polypeptide antibodyAnti-Nf-L antibodyAnti-68 Kda Neurofilament Protein antibodyAnti-Neurofilament Triplet L Protein antibodyAnti-NEFL antibodyAnti-NF68 antibodyAnti-NFL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance