| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sialidase-3 (132-182 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NEU3 |
| Gene ID: |
10825 |
| Uniprot ID: |
NEUR3_HUMAN |
| Immunogen Region: |
132-182 aa |
| Specificity: |
This antibody detects endogenous levels of NEUR3 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human NEUR3 at the amino acid range 132-182 |
| Post Translational Modifications | Palmitoylated.may regulate intracellular trafficking and anchorage to plasma membrane and endomembranes. |
| Function | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes. |
| Protein Name | Sialidase-3Ganglioside SialidasedisMembrane SialidaseN-Acetyl-Alpha-Neuraminidase 3 |
| Database Links | Reactome: R-HSA-1660662Reactome: R-HSA-4085001 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinMembraneCaveolaEarly Endosome MembraneRecycling Endosome MembraneLysosome MembraneAssociates With The External Leaflet Of The Plasma MembraneS-Acylated Neu3 Likely Spans The Lipid Bilayer With A Portion Of C-Terminus Exposed To The Cytosol And The Catalytic Region Facing The Extracellular Space |
| Alternative Antibody Names | Anti-Sialidase-3 antibodyAnti-Ganglioside Sialidasedis antibodyAnti-Membrane Sialidase antibodyAnti-N-Acetyl-Alpha-Neuraminidase 3 antibodyAnti-NEU3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
