Anti-NEU2 antibody (171-380) (STJ110436)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NEU2 (171-380) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NEU2 |
| Gene ID | 4759 |
| Uniprot ID | NEUR2_HUMAN |
| Immunogen Region | 171-380 |
| Immunogen Sequence | ARSLVVPAYAYRKLHPIQRP IPSAFCFLSHDHGRTWARGH FVAQDTLECQVAEVETGEQR VVTLNARSHLRARVQAQSTN DGLDFQESQLVKKLVEPPPQ GCQGSVISFPSPRSGPGSPA QWLLYTHPTHSWQRADLGAY LNPRPPAPEAWSEPVLLAKG SCAYSDLQSMGTGPDGSPLF GCLYEANDYEEIVFLMFTLK QAFPAEYLPQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 171-380 of human NEU2 (NP_005374.2). |
Additional Info
| Tissue Specificity | Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1. |
| Function | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues. |
| Protein Name | Sialidase-2Cytosolic SialidaseN-Acetyl-Alpha-Neuraminidase 2 |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-9840310 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Sialidase-2 antibodyAnti-Cytosolic Sialidase antibodyAnti-N-Acetyl-Alpha-Neuraminidase 2 antibodyAnti-NEU2 antibody |
Information sourced from Uniprot.org