| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NEU2 |
| Gene ID: | 4759 |
| Uniprot ID: | NEUR2_HUMAN |
| Immunogen Region: | 171-380 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 171-380 of human NEU2 (NP_005374.2). |
| Immunogen Sequence: | ARSLVVPAYAYRKLHPIQRP IPSAFCFLSHDHGRTWARGH FVAQDTLECQVAEVETGEQR VVTLNARSHLRARVQAQSTN DGLDFQESQLVKKLVEPPPQ GCQGSVISFPSPRSGPGSPA QWLLYTHPTHSWQRADLGAY LNPRPPAPEAWSEPVLLAKG SCAYSDLQSMGTGPDGSPLF GCLYEANDYEEIVFLMFTLK QAFPAEYLPQ |
| Tissue Specificity | Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1. |
| Function | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues. |
| Protein Name | Sialidase-2 Cytosolic Sialidase N-Acetyl-Alpha-Neuraminidase 2 |
| Database Links | Reactome: R-HSA-4085001 Reactome: R-HSA-9840310 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative Antibody Names | Anti-Sialidase-2 antibody Anti-Cytosolic Sialidase antibody Anti-N-Acetyl-Alpha-Neuraminidase 2 antibody Anti-NEU2 antibody |
Information sourced from Uniprot.org