| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NEU1 (210-415) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NEU1 |
| Gene ID: |
4758 |
| Uniprot ID: |
NEUR1_HUMAN |
| Immunogen Region: |
210-415 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 210-415 of human NEU1 (NP_000425.1). |
| Immunogen Sequence: |
PRKGRLIVCGHGTLERDGVF CLLSDDHGASWRYGSGVSGI PYGQPKQENDFNPDECQPYE LPDGSVVINARNQNNYHCHC RIVLRSYDACDTLRPRDVTF DPELVDPVVAAGAVVTSSGI VFFSNPAHPEFRVNLTLRWS FSNGTSWRKETVQLWPGPSG YSSLATLEGSMDGEEQAPQL YVLYEKGRNHYTESISVAKI SVYGTL |
| Tissue Specificity | Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain. |
| Post Translational Modifications | N-glycosylated. Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane. |
| Function | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. |
| Protein Name | Sialidase-1Acetylneuraminyl HydrolaseG9 SialidaseLysosomal SialidaseN-Acetyl-Alpha-Neuraminidase 1 |
| Database Links | Reactome: R-HSA-1660662Reactome: R-HSA-4085001Reactome: R-HSA-4341670Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome MembranePeripheral Membrane ProteinLumenal SideLysosome LumenCell MembraneCytoplasmic VesicleLysosomeLocalized Not Only On The Inner Side Of The Lysosomal Membrane And In The Lysosomal LumenBut Also On The Plasma Membrane And In Intracellular Vesicles |
| Alternative Antibody Names | Anti-Sialidase-1 antibodyAnti-Acetylneuraminyl Hydrolase antibodyAnti-G9 Sialidase antibodyAnti-Lysosomal Sialidase antibodyAnti-N-Acetyl-Alpha-Neuraminidase 1 antibodyAnti-NEU1 antibodyAnti-NANH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
