| Short Description : | Chicken polyclonal anti-Nerve growth factor (74-85 & 113-124 aa) for use in ELISA, IHC-F and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | ELISA/IHC-F/WB |
| Host: | Chicken |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgY |
| Conjugation: | Unconjugated |
| Purification: | Affinity-purified |
| Dilution Range: | WB 1:500-1:2000IHC 1:50-1:1000 |
| Formulation: | PBS with 0.02% sodium azide. |
| Storage Instruction: | Short term storage at 2-8°C for one week. At-20°C as an undiluted liquid for up to 12 months. |
| Gene Symbol: | NGF |
| Gene ID: | 4803 |
| Uniprot ID: | NGF_HUMAN |
| Immunogen: | Mixture of two mouse beta NGF peptides (74-85 and 113-124 aa). |
| Immunogen Region: | 74-85 & 113-124 aa |
| Immunogen Sequence: | Mouse |
| Specificity: | Human beta NGF, cross reactivity to other species NGF is expected. |
| Function | Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form. |
| Protein Name | Beta-Nerve Growth FactorBeta-Ngf |
| Database Links | Reactome: R-HSA-167021Reactome: R-HSA-167044Reactome: R-HSA-167060Reactome: R-HSA-170968Reactome: R-HSA-170984Reactome: R-HSA-177504Reactome: R-HSA-187042Reactome: R-HSA-187706Reactome: R-HSA-193648Reactome: R-HSA-193670Reactome: R-HSA-193681Reactome: R-HSA-198203Reactome: R-HSA-198745Reactome: R-HSA-205017Reactome: R-HSA-205025Reactome: R-HSA-205043Reactome: R-HSA-209543Reactome: R-HSA-209560Reactome: R-HSA-209563 |
| Cellular Localisation | SecretedEndosome LumenProngf Is Endocytosed After Binding To The Cell Surface Receptor Formed By Sort1 And Ngfr |
| Alternative Antibody Names | Anti-Beta-Nerve Growth Factor antibodyAnti-Beta-Ngf antibodyAnti-NGF antibodyAnti-NGFB antibody |
Information sourced from Uniprot.org