| Host: | Mouse |
| Applications: | WB/IHC/ICC |
| Reactivity: | Bovine/Chicken/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-NEFL/NF-L is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | DA2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | 100 ul in PBS + 10 mM Sodium Azide. |
| Purification: | This antibody was protein g purified culture from supernatant. |
| Dilution Range: | WB 1:1000 IHC 1:100-1:1000 ICC 1:100-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Post Translational Modifications | O-glycosylated. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. Ubiquitinated in the presence of TRIM2 and UBE2D1. |
| Function | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. |
| Protein Name | Neurofilament Light Polypeptide Nf-L 68 Kda Neurofilament Protein Neurofilament Triplet L Protein |
| Database Links | Reactome: R-HSA-438066 Reactome: R-HSA-442982 Reactome: R-HSA-5673001 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell Projection Axon Cytoplasm Cytoskeleton |
| Alternative Antibody Names | Anti-Neurofilament Light Polypeptide antibody Anti-Nf-L antibody Anti-68 Kda Neurofilament Protein antibody Anti-Neurofilament Triplet L Protein antibody Anti-NEFL antibody Anti-NF68 antibody Anti-NFL antibody |
Information sourced from Uniprot.org