• Western blot analysis of lysate from HeLa cells, using PVRL3 Antibody.
  • Western blot analysis of HeLa cells using Nectin 3 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-NECTIN3 antibody (311-360 aa) (STJ96626)

SKU:
STJ96626

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Nectin-3 (311-360 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NECTIN3
Gene ID: 25945
Uniprot ID: NECT3_HUMAN
Immunogen Region: 311-360 aa
Specificity: Nectin 3 Polyclonal Antibody detects endogenous levels of Nectin 3 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human PVRL3 at the amino acid range 311-360
Function Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Protein Name Nectin-3
Cdw113
Nectin Cell Adhesion Molecule 3
Poliovirus Receptor-Related Protein 3
Cd Antigen Cd113
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Membrane Protein
Postsynaptic Cell Membrane
Alternative Antibody Names Anti-Nectin-3 antibody
Anti-Cdw113 antibody
Anti-Nectin Cell Adhesion Molecule 3 antibody
Anti-Poliovirus Receptor-Related Protein 3 antibody
Anti-Cd Antigen Cd113 antibody
Anti-NECTIN3 antibody
Anti-PRR3 antibody
Anti-PVRL3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance