Anti-NDUFS2 antibody (Internal) (STJ72300)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NDUFS2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 48kDa band observed in Human, Mouse and Rat Heart lysates (calculated MW of 51.9kDa according to NP_001159631.1). Recommended concentration: 0.1-0.3ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NDUFS2 |
| Gene ID | 4720 |
| Uniprot ID | NDUS2_HUMAN |
| Accession Number | NP_004541.1; NP_001159631.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | SRGVRQWQPDVE |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_004541.1; NP_001159631.1). |
Additional Info
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. Essential for the assembly of complex I. Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction. Plays an important role in carotid body sensing of hypoxia. Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation. |
| Protein Name | Nadh Dehydrogenase Ubiquinone Iron-Sulfur Protein 2 - MitochondrialComplex I-49kdCi-49kdNadh-Ubiquinone Oxidoreductase 49 Kda Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-6799198 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Antibody Names | Anti-Nadh Dehydrogenase Ubiquinone Iron-Sulfur Protein 2 - Mitochondrial antibodyAnti-Complex I-49kd antibodyAnti-Ci-49kd antibodyAnti-Nadh-Ubiquinone Oxidoreductase 49 Kda Subunit antibodyAnti-NDUFS2 antibody |
Information sourced from Uniprot.org