Anti-NDRG4 antibody (140-220) (STJ118635)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NDRG4 (140-220) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NDRG4 |
| Gene ID | 65009 |
| Uniprot ID | NDRG4_HUMAN |
| Immunogen Region | 140-220 |
| Immunogen Sequence | DPNGKGWIDWAATKLSGLTS TLPDTVLSHLFSQEELVNNT ELVQSYRQQIGNVVNQANLQ LFWNMYNSRRDLDINRPGTV P |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human NDRG4 (NP_001229765.1). |
Additional Info
| Tissue Specificity | Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. |
| Post Translational Modifications | Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment. |
| Function | Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. |
| Protein Name | Protein Ndrg4Brain Development-Related Molecule 1N-Myc Downstream-Regulated Gene 4 ProteinVascular Smooth Muscle Cell-Associated Protein 8Smap-8 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Ndrg4 antibodyAnti-Brain Development-Related Molecule 1 antibodyAnti-N-Myc Downstream-Regulated Gene 4 Protein antibodyAnti-Vascular Smooth Muscle Cell-Associated Protein 8 antibodyAnti-Smap-8 antibodyAnti-NDRG4 antibodyAnti-BDM1 antibodyAnti-KIAA1180 antibody |
Information sourced from Uniprot.org