| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NDRG2 (138-357) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NDRG2 |
| Gene ID: |
57447 |
| Uniprot ID: |
NDRG2_HUMAN |
| Immunogen Region: |
138-357 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 138-357 of human NDRG2 (NP_963832.1). |
| Immunogen Sequence: |
LARYALNHPDTVEGLVLINI DPNAKGWMDWAAHKLTGLTS SIPEMILGHLFSQEELSGNS ELIQKYRNIITHAPNLDNIE LYWNSYNNRRDLNFERGGDI TLRCPVMLVVGDQAPHEDAV VECNSKLDPTQTSFLKMADS GGQPQLTQPGKLTEAFKYFL QGMGYMASSCMTRLSRSRTA SLTSAASVDGNRSRSRTLSQ SSESGTLSSGPPGHTMEVSC |
| Tissue Specificity | Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues.absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). |
| Function | Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. |
| Protein Name | Protein Ndrg2N-Myc Downstream-Regulated Gene 2 ProteinProtein Syld709613 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell ProjectionGrowth ConeIn NeuronsSeems To Concentrate At Axonal Growth ConePerinuclear In Neurons |
| Alternative Antibody Names | Anti-Protein Ndrg2 antibodyAnti-N-Myc Downstream-Regulated Gene 2 Protein antibodyAnti-Protein Syld709613 antibodyAnti-NDRG2 antibodyAnti-KIAA1248 antibodyAnti-SYLD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
