Anti-NDR1/STK38 antibody (C-Term) (STJ72524)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NDR1/STK38 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 55kDa band observed in Human and Rat Spleen lysates (calculated MW of 54.2kDa according to NP_009202.1). Recommended concentration: 0.5-2µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | STK38 |
| Gene ID | 11329 |
| Uniprot ID | STK38_HUMAN |
| Accession Number | NP_009202.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | KPTVATSNHPET |
| Specificity | This antibody is NOT expected to cross-react with STK38L (GeneID 23012). |
Additional Info
| Post Translational Modifications | ISGylated. Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. |
| Function | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation. |
| Protein Name | Serine/Threonine-Protein Kinase 38Ndr1 Protein KinaseNuclear Dbf2-Related Kinase 1 |
| Database Links | Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusCytoplasmChromosomeLocalizes To Dna Double-Strand Breaks In Response To Dna Damage |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 38 antibodyAnti-Ndr1 Protein Kinase antibodyAnti-Nuclear Dbf2-Related Kinase 1 antibodyAnti-STK38 antibodyAnti-NDR1 antibody |
Information sourced from Uniprot.org