Anti-NDP antibody (25-133) (STJ24710)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NDP (25-133) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NDP |
| Gene ID | 4693 |
| Uniprot ID | NDP_HUMAN |
| Immunogen Region | 25-133 |
| Immunogen Sequence | KTDSSFIMDSDPRRCMRHHY VDSISHPLYKCSSKMVLLAR CEGHCSQASRSEPLVSFSTV LKQPFRSSCHCCRPQTSKLK ALRLRCSGGMRLTATYRYIL SCHCEECNS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 25-133 of human NDP (NP_000257.1). |
Additional Info
| Tissue Specificity | Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain. |
| Function | Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. |
| Protein Name | NorrinNorrie Disease ProteinX-Linked Exudative Vitreoretinopathy 2 Protein |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Norrin antibodyAnti-Norrie Disease Protein antibodyAnti-X-Linked Exudative Vitreoretinopathy 2 Protein antibodyAnti-NDP antibodyAnti-EVR2 antibody |
Information sourced from Uniprot.org