Function | NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the 2Fe-2S cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the 2Fe-2S cluster of CISD1 and activate this protein implicated in Fe/S cluster repair. In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A. |
Protein Name | Nadph-Dependent Diflavin Oxidoreductase 1Nadph-Dependent Fmn And Fad-Containing OxidoreductaseNovel Reductase 1 |
Database Links | Reactome: R-HSA-2564830 |
Cellular Localisation | CytoplasmPerinuclear RegionConcentrated In Perinuclear Structure |
Alternative Antibody Names | Anti-Nadph-Dependent Diflavin Oxidoreductase 1 antibodyAnti-Nadph-Dependent Fmn And Fad-Containing Oxidoreductase antibodyAnti-Novel Reductase 1 antibodyAnti-NDOR1 antibodyAnti-NR1 antibody |
Information sourced from Uniprot.org