Anti-NDN antibody (101-151 aa) (STJ197663)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human NECD at the amino acid range 101-151
General Information
| Short Description | Rabbit polyclonal anti-Necdin (101-151 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NDN |
| Gene ID | 4692 |
| Uniprot ID | NECD_HUMAN |
| Immunogen | Synthesized peptide derived from the human NECD at the amino acid range 101-151 |
| Immunogen Region | 101-151 aa |
| Specificity | This antibody detects endogenous levels of human NECD |
Additional Info
| Function | Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences. |
| Protein Name | Necdin |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | PerikaryonNucleusNeural PerikaryaTranslocates To The Nucleus Of Postmitotic Neurons And Interacts With The Nuclear Matrix |
| Alternative Antibody Names | Anti-Necdin antibodyAnti-NDN antibody |
Information sourced from Uniprot.org