| Post Translational Modifications | Ubiquitinated by NEDD4 and ITCH. Also ubiquitinated by NEDD4L. Ubiquitination by NEDD4 or NEDD4L does not affect turnover. Undergoes transient tyrosine-phosphorylation following EGF stimulation, most probably catalyzed by SRC. Phosphorylation on Tyr-151, Tyr-171 and Tyr-177 are dependent on the phosphorylation on Tyr-167. Also phosphorylated by LYN and FYN. |
| Function | Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. |
| Protein Name | Nedd4 Family-Interacting Protein 2Nedd4 Ww Domain-Binding Protein 5aPutative Mapk-Activating Protein Pm04/Pm05/Pm06/Pm07Putative Nf-Kappa-B-Activating Protein 413 |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneEndosomeMultivesicular Body Membrane |
| Alternative Antibody Names | Anti-Nedd4 Family-Interacting Protein 2 antibodyAnti-Nedd4 Ww Domain-Binding Protein 5a antibodyAnti-Putative Mapk-Activating Protein Pm04/Pm05/Pm06/Pm07 antibodyAnti-Putative Nf-Kappa-B-Activating Protein 413 antibodyAnti-NDFIP2 antibodyAnti-KIAA1165 antibodyAnti-N4WBP5A antibody |
Information sourced from Uniprot.org
