Anti-NDC80/HEC1 antibody [9G3] (STJA0022358)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Kinetochore Protein Ndc80 Homolog antibody for use in FC, ICC, IF, IP and WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/ICC/IF/IP/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 9G3 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | NDC80 |
| Gene ID | 10403 |
| Uniprot ID | NDC80_HUMAN |
Additional Info
| Function | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules. |
| Protein Name | Kinetochore Protein Ndc80 HomologHighly Expressed In Cancer ProteinKinetochore Protein Hec1Hshec1Kinetochore-Associated Protein 2Retinoblastoma-Associated Protein Hec |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes To Kinetochores From Late Prophase To AnaphaseLocalizes Specifically To The Outer Plate Of The Kinetochore |
| Alternative Antibody Names | Anti-Kinetochore Protein Ndc80 Homolog antibodyAnti-Highly Expressed In Cancer Protein antibodyAnti-Kinetochore Protein Hec1 antibodyAnti-Hshec1 antibodyAnti-Kinetochore-Associated Protein 2 antibodyAnti-Retinoblastoma-Associated Protein Hec antibodyAnti-NDC80 antibodyAnti-HEC antibodyAnti-HEC1 antibodyAnti-KNTC2 antibody |
Information sourced from Uniprot.org