Anti-NCS1 antibody (1-190) (STJ115547)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NCS1 (1-190) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NCS1 |
| Gene ID | 23413 |
| Uniprot ID | NCS1_HUMAN |
| Immunogen Region | 1-190 |
| Immunogen Sequence | MGKSNSKLKPEVVEELTRKT YFTEKEVQQWYKGFIKDCPS GQLDAAGFQKIYKQFFPFGD PTKFATFVFNVFDENKDGRI EFSEFIQALSVTSRGTLDEK LRWAFKLYDLDNDGYITRNE MLDIVDAIYQMVGNTVELPE EENTPEKRVDRIFAMMDKNA DGKLTLQEFQEGSKADPSIV QALSLYDGLV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human NCS1 (NP_055101.2). |
Additional Info
| Function | Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel. |
| Protein Name | Neuronal Calcium Sensor 1Ncs-1Frequenin HomologFrequenin-Like ProteinFrequenin-Like Ubiquitous Protein |
| Database Links | |
| Cellular Localisation | Golgi ApparatusPostsynaptic DensityCytoplasmPerinuclear RegionCell MembranePeripheral Membrane ProteinMembraneLipid-AnchorAssociated With Golgi StacksPost-Synaptic Densities Of DendritesAnd In The Pre-Synaptic Nerve Terminal At Neuromuscular Junctions |
| Alternative Antibody Names | Anti-Neuronal Calcium Sensor 1 antibodyAnti-Ncs-1 antibodyAnti-Frequenin Homolog antibodyAnti-Frequenin-Like Protein antibodyAnti-Frequenin-Like Ubiquitous Protein antibodyAnti-NCS1 antibodyAnti-FLUP antibodyAnti-FREQ antibody |
Information sourced from Uniprot.org