Anti-NCOR1 antibody (51-100) (STJ94364)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human NCoR1. AA range:51-100
General Information
| Short Description | Rabbit polyclonal anti-Nuclear receptor corepressor 1 (51-100) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NCOR1 |
| Gene ID | 9611 |
| Uniprot ID | NCOR1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NCoR1. AA range:51-100 |
| Immunogen Region | 51-100 |
| Specificity | N-CoR Polyclonal Antibody detects endogenous levels of N-CoR protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated.mediated by SIAH2 and leading to its subsequent proteasomal degradation. |
| Function | Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver. |
| Protein Name | Nuclear Receptor Corepressor 1N-CorN-Cor1 |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-1368071Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-2151201Reactome: R-HSA-2173795Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-5617472Reactome: R-HSA-9022537Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9609690Reactome: R-HSA-9623433Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Corepressor 1 antibodyAnti-N-Cor antibodyAnti-N-Cor1 antibodyAnti-NCOR1 antibodyAnti-KIAA1047 antibody |
Information sourced from Uniprot.org