| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-NCOA2 (550-820) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCOA2 |
| Gene ID: | 10499 |
| Uniprot ID: | NCOA2_HUMAN |
| Immunogen Region: | 550-820 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-820 of human NCOA2 (NP_006531.1). |
| Immunogen Sequence: | SSLASPDLKMGNLQNSPVNM NPPPLSKMGSLDSKDCFGLY GEPSEGTTGQAESSCHPGEQ KETNDPNLPPAVSSERADGQ SRLHDSKGQTKLLQLLTTKS DQMEPSPLASSLSDTNKDST GSLPGSGSTHGTSLKEKHKI LHRLLQDSSSPVDLAKLTAE ATGKDLSQESSSTAPGSEVT IKQEPVSPKKKENALLRYLL DKDDTKDIGLPEITPKLERL DSKTDPASNTKLIAMKTEK |
| Post Translational Modifications | Acetylated. Deacetylation at Lys-780 by SIRT6 stimulates its ability to coactivate PPARA. |
| Function | Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer. |
| Protein Name | Nuclear Receptor Coactivator 2Ncoa-2Class E Basic Helix-Loop-Helix Protein 75Bhlhe75Transcriptional Intermediary Factor 2Htif2 |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-159418Reactome: R-HSA-192105Reactome: R-HSA-193368Reactome: R-HSA-193807Reactome: R-HSA-1989781Reactome: R-HSA-211976Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-3214847Reactome: R-HSA-381340Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-5625886Reactome: R-HSA-9018519Reactome: R-HSA-9707564Reactome: R-HSA-9707616 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Coactivator 2 antibodyAnti-Ncoa-2 antibodyAnti-Class E Basic Helix-Loop-Helix Protein 75 antibodyAnti-Bhlhe75 antibodyAnti-Transcriptional Intermediary Factor 2 antibodyAnti-Htif2 antibodyAnti-NCOA2 antibodyAnti-BHLHE75 antibodyAnti-SRC2 antibodyAnti-TIF2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
