| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Condensin complex subunit 1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCAPD2 |
| Gene ID: | 9918 |
| Uniprot ID: | CND1_HUMAN |
| Specificity: | This antibody detects endogenous levels of NCAPD2 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human NCAPD2 |
| Function | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. |
| Protein Name | Condensin Complex Subunit 1 Chromosome Condensation-Related Smc-Associated Protein 1 Chromosome-Associated Protein D2 Hcap-D2 Non-Smc Condensin I Complex Subunit D2 Xcap-D2 Homolog |
| Database Links | Reactome: R-HSA-2514853 |
| Cellular Localisation | Nucleus Cytoplasm Chromosome In Interphase Cells The Majority Of The Condensin Complex Is Found In The Cytoplasm While A Minority Of The Complex Is Associated With Chromatin A Subpopulation Of The Complex However Remains Associated With Chromosome Foci In Interphase Cells During Mitosis Most Of The Condensin Complex Is Associated With The Chromatin At The Onset Of Prophase The Regulatory Subunits Of The Complex Are Phosphorylated By Cdk1 Leading To Condensin's Association With Chromosome Arms And To Chromosome Condensation Dissociation From Chromosomes Is Observed In Late Telophase |
| Alternative Antibody Names | Anti-Condensin Complex Subunit 1 antibody Anti-Chromosome Condensation-Related Smc-Associated Protein 1 antibody Anti-Chromosome-Associated Protein D2 antibody Anti-Hcap-D2 antibody Anti-Non-Smc Condensin I Complex Subunit D2 antibody Anti-Xcap-D2 Homolog antibody Anti-NCAPD2 antibody Anti-CAPD2 antibody Anti-CNAP1 antibody Anti-KIAA0159 antibody |
Information sourced from Uniprot.org