Anti-NCAM1 antibody (1-718 ECD) (STJA0040617)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenHuman NCAM1 1-718 (Extracellular region)
General Information
| Short Description | Chicken polyclonal anti-NCAM1 (1-718 ECD) for use in ICC, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IHC/WB |
| Host | Chicken |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Concentration | 200 µg/mL |
| Purification | Affinity-Purified IgY |
| Dilution Range | WB 1:2000-1:10000WB Brain 1:2000-1:10000IHC 1:200-1:500ICC 1:200-1:500 |
| Formulation | Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS, pH 7.2) with sodium azide (0.02%, w/v) added as a preservative." |
| Storage Instruction | Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody. |
Target Information
| Gene Symbol | NCAM1 |
| Gene ID | 4684 |
| Uniprot ID | NCAM1_HUMAN |
| Immunogen | Human NCAM1 1-718 (Extracellular region) |
| Immunogen Region | 1-718 ECD |
| Immunogen Sequence | Human |
| Specificity | No cross-reactivity reported |
Additional Info
| Post Translational Modifications | Polysialylated at Asn-459 and Asn-488 by ST8SIA2 and ST8SIA4. Polysialylation modulates cell interactions by confering both attractive and repulsive properties that are highly regulated by ST8SIA2 and ST8SIA4. Polysialylation is formed on a-2,3-linked sialic acid of core glycans. |
| Function | This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. (Microbial infection) Acts as a receptor for rabies virus. (Microbial infection) Acts as a receptor for Zika virus. |
| Protein Name | Neural Cell Adhesion Molecule 1N-Cam-1Ncam-1Cd Antigen Cd56 |
| Database Links | Reactome: R-HSA-3000178Reactome: R-HSA-375165Reactome: R-HSA-419037Reactome: R-HSA-445144Reactome: R-HSA-5673001Reactome: R-HSA-877300 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneIsoform 3: Cell MembraneLipid-AnchorGpi-AnchorIsoform 4: Cell MembraneIsoform 5: SecretedIsoform 6: Secreted |
| Alternative Antibody Names | Anti-Neural Cell Adhesion Molecule 1 antibodyAnti-N-Cam-1 antibodyAnti-Ncam-1 antibodyAnti-Cd Antigen Cd56 antibodyAnti-NCAM1 antibodyAnti-NCAM antibody |
Information sourced from Uniprot.org