Anti-NCAM antibody [123C3] (STJ16100875)

SKU:

STJ16100875-1

£445.50

General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	IHC-P/IHC-F/IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-CD56 is suitable for use in Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	123C3
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	PBS with 0.1% BSA and 0.02% sodium azide
Concentration:	100 ug/mL
Dilution Range:	IF 1:50 IHC 1:50
Storage Instruction:	Store at 2-8°C upon receipt.

Background

The antibody recognizes a transmembrane glycoprotein of 140 and 180 kD which has been identified as NCAM (Neural Cell Adhesion Module). At the international Workshop on SCLC antibodies 123C3 has been categorized as cluster 1 antibody. All cells in small cell carcinomas and carcinoids of the lung are strongly positive for 123C3. A minority of cases of other major types of lung carcinoma are sometimes positive as well: however this positivity is generally weak and focal. Adenoid cystic carcinomas of bronchial glands are strongly positive. Neuroblastoma s and Wilms tumors are usually also staining strongly positive. In non-small lung cell carcinomas, 123C3 staining has been associated with more advanced stage and a decreased survival after surgery. Furthermore, this antibody can be used to support diagnosis of lymphoma or to detect residual disease for cases of CD56 positive T/NK-cell lymphoma in which the neoplastic lymphoid cells are small and show minimal atypia, especially in small biopsies.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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