Anti-NAT8 antibody (38-88) (STJA0006592)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NAT8 AA range: 38-88
General Information
| Short Description | Rabbit polyclonal anti-N-acetyltransferase 8 (38-88) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NAT8 |
| Gene ID | 9027 |
| Uniprot ID | NAT8_HUMAN |
| Immunogen | Synthesized peptide derived from human NAT8 AA range: 38-88 |
| Immunogen Region | 38-88 |
| Specificity | This antibody detects endogenous levels of human NAT8 |
Additional Info
| Function | Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons. N(6)-lysine acetylation in the ER maintains protein homeostasis and regulates reticulophagy. Alternatively, acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. |
| Protein Name | N-Acetyltransferase 8Acetyltransferase 2Atase2Camello-Like Protein 1Cysteinyl-Conjugate N-AcetyltransferaseCcnatProtein-Lysine N6-Acetyltransferase 8 |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | Endoplasmic Reticulum-Golgi Intermediate Compartment MembraneSingle-Pass Type Ii Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-N-Acetyltransferase 8 antibodyAnti-Acetyltransferase 2 antibodyAnti-Atase2 antibodyAnti-Camello-Like Protein 1 antibodyAnti-Cysteinyl-Conjugate N-Acetyltransferase antibodyAnti-Ccnat antibodyAnti-Protein-Lysine N6-Acetyltransferase 8 antibodyAnti-NAT8 antibodyAnti-CML1 antibodyAnti-GLA antibodyAnti-TSC501 antibody |
Information sourced from Uniprot.org