Anti-NASP antibody (680-760 aa) (STJ191088)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 680-760
General Information
| Short Description | Rabbit polyclonal anti-Nuclear autoantigenic sperm protein (680-760 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NASP |
| Gene ID | 4678 |
| Uniprot ID | NASP_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 680-760 |
| Immunogen Region | 680-760 aa |
| Specificity | NASP Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Component of the histone chaperone network. Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy. Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. Isoform 1: Stabilizes soluble histone H3-H4. Isoform 2: Stabilizes soluble histone H3-H4. |
| Protein Name | Nuclear Autoantigenic Sperm ProteinNasp |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Nuclear Autoantigenic Sperm Protein antibodyAnti-Nasp antibodyAnti-NASP antibody |
Information sourced from Uniprot.org