| Post Translational Modifications | Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. |
| Function | Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. |
| Protein Name | Nicotinate PhosphoribosyltransferaseNaprtaseFha-Hit-Interacting ProteinNicotinate Phosphoribosyltransferase Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Nicotinate Phosphoribosyltransferase antibodyAnti-Naprtase antibodyAnti-Fha-Hit-Interacting Protein antibodyAnti-Nicotinate Phosphoribosyltransferase Domain-Containing Protein 1 antibodyAnti-NAPRT antibodyAnti-FHIP antibodyAnti-NAPRT1 antibody |
Information sourced from Uniprot.org
