| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NAPRT (309-538) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NAPRT |
| Gene ID: |
93100 |
| Uniprot ID: |
PNCB_HUMAN |
| Immunogen Region: |
309-538 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 309-538 of human NAPRT1 (NP_660202.3). |
| Immunogen Sequence: |
ELGYRAVGVRLDSGDLLQQA QEIRKVFRAAAAQFQVPWLE SVLIVVSNNIDEEALARLAQ EGSEVNVIGIGTSVVTCPQQ PSLGGVYKLVAVGGQPRMKL TEDPEKQTLPGSKAAFRLLG SDGSPLMDMLQLAEEPVPQA GQELRVWPPGAQEPCTVRPA QVEPLLRLCLQQGQLCEPLP SLAESRALAQLSLSRLSPEH RRLRSPAQYQVVLSERLQAL VNSLCAGQSP |
| Post Translational Modifications | Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. |
| Function | Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. |
| Protein Name | Nicotinate PhosphoribosyltransferaseNaprtaseFha-Hit-Interacting ProteinNicotinate Phosphoribosyltransferase Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Nicotinate Phosphoribosyltransferase antibodyAnti-Naprtase antibodyAnti-Fha-Hit-Interacting Protein antibodyAnti-Nicotinate Phosphoribosyltransferase Domain-Containing Protein 1 antibodyAnti-NAPRT antibodyAnti-FHIP antibodyAnti-NAPRT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
