| Short Description : | Rabbit polyclonal anti-Nanos homolog 3 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NANOS3 |
| Gene ID: | 342977 |
| Uniprot ID: | NANO3_HUMAN |
| Immunogen: | Synthesized peptide derived from human NANOS3 |
| Specificity: | This antibody detects endogenous levels of NANOS3 at Human, Mouse |
| Function | Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. |
| Protein Name | Nanos Homolog 3Nos-3 |
| Database Links | Reactome: R-HSA-9827857 |
| Cellular Localisation | NucleusCytoplasmStress GranuleP-BodyCo-Localizes With Pum2Eif2s1 And Tial1 In The Stress GranulesCo-Localizes With Dcp1a In The P-Body |
| Alternative Antibody Names | Anti-Nanos Homolog 3 antibodyAnti-Nos-3 antibodyAnti-NANOS3 antibodyAnti-NOS3 antibody |
Information sourced from Uniprot.org
