Anti-NAMPT antibody (200-300) {Biotin} (STJ503511)

SKU:
STJ503511-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Chicken/Human/Mouse/Pig/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NAMPT (200-300) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.68-0.70 µg/µl
Dilution Range: WB: 1:500
DB: 1:4, 000
ELISA: 1:4, 000
IP: 1:150
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NAMPT
Gene ID: 10135
Uniprot ID: NAMPT_HUMAN
Immunogen Region: 200-300
Immunogen: N-epitope synthetic peptide taken within amino acid region 200-300 on human Visfatin protein.
Tissue Specificity Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Function Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
Protein Name Nicotinamide Phosphoribosyltransferase
Namprtase
Nampt
Pre-B-Cell Colony-Enhancing Factor 1
Pre-B Cell-Enhancing Factor
Visfatin
Database Links Reactome: R-HSA-1368108
Reactome: R-HSA-197264
Reactome: R-HSA-9768919
Cellular Localisation Nucleus
Cytoplasm
Secreted
Under Non-Inflammatory Conditions
Visfatin Predominantly Exhibits A Granular Pattern Within The Nucleus
Secreted By Endothelial Cells Upon Il-1beta Stimulation
Abundantly Secreted In Milk
Reaching 100-Fold Higher Concentrations Compared To Maternal Serum
Alternative Antibody Names Anti-Nicotinamide Phosphoribosyltransferase antibody
Anti-Namprtase antibody
Anti-Nampt antibody
Anti-Pre-B-Cell Colony-Enhancing Factor 1 antibody
Anti-Pre-B Cell-Enhancing Factor antibody
Anti-Visfatin antibody
Anti-NAMPT antibody
Anti-PBEF antibody
Anti-PBEF1 antibody

Information sourced from Uniprot.org

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