Anti-NAGK antibody (50-210) (STJ111552)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NAGK (50-210) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NAGK |
| Gene ID | 55577 |
| Uniprot ID | NAGK_HUMAN |
| Immunogen Region | 50-210 |
| Immunogen Sequence | IYGGVEGGGTRSEVLLVSED GKILAEADGLSTNHWLIGTD KCVERINEMVNRAKRKAGVD PLVPLRSLGLSLSGGDQEDA GRILIEELRDRFPYLSESYL ITTDAAGSIATATPDGGVVL ISGTGSNCRLINPDGSESGC GGWGHMMGDEGSAYWIAHQA V |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 50-210 of human NAGK (NP_060037.3). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has N-acetylmannosamine (ManNAc) kinase activity. Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2. |
| Protein Name | N-Acetyl-D-Glucosamine KinaseN-Acetylglucosamine KinaseGlcnac KinaseMuramyl Dipeptide KinaseN-Acetyl-D-Mannosamine Kinase |
| Database Links | Reactome: R-HSA-446210 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-N-Acetyl-D-Glucosamine Kinase antibodyAnti-N-Acetylglucosamine Kinase antibodyAnti-Glcnac Kinase antibodyAnti-Muramyl Dipeptide Kinase antibodyAnti-N-Acetyl-D-Mannosamine Kinase antibodyAnti-NAGK antibody |
Information sourced from Uniprot.org