• Western blot analysis of various lysates using NACC1 Rabbit polyclonal antibody (STJ113847) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-NACC1 antibody (170-340) (STJ113847)

SKU:
STJ113847

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NACC1 (170-340) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NACC1
Gene ID: 112939
Uniprot ID: NACC1_HUMAN
Immunogen Region: 170-340
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 170-340 of human NACC1 (NP_443108.1).
Immunogen Sequence: QQESDSVQCMPVAKRLWDSG QKEAGGGGNGSRKMAKFSTP DLAANRPHQPPPPQQAPVVA AAQPAVAAGAGQPAGGVAAA GGVVSGPSTSERTSPGTSSA YTSDSPGSYHNEEDEEEDGG EEGMDEQYRQICNMYTMYSM MNVGQTAEKVEALPEQVAPE SRNRIRVRQDL
Tissue Specificity Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
Function Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
Protein Name Nucleus Accumbens-Associated Protein 1
Nac-1
Btb/Poz Domain-Containing Protein 14b
Cellular Localisation Nucleus
Cytoplasm
Distribution In The Cytoplasm Is Dependent On Phosphorylation
Alternative Antibody Names Anti-Nucleus Accumbens-Associated Protein 1 antibody
Anti-Nac-1 antibody
Anti-Btb/Poz Domain-Containing Protein 14b antibody
Anti-NACC1 antibody
Anti-BTBD14B antibody
Anti-NAC1 antibody

Information sourced from Uniprot.org

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