Anti-NABP2 antibody (70-120) (STJA0006368)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SOSB1 AA range: 70-120
General Information
| Short Description | Rabbit polyclonal anti-SOSS complex subunit B1 (70-120) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NABP2 |
| Gene ID | 79035 |
| Uniprot ID | SOSB1_HUMAN |
| Immunogen | Synthesized peptide derived from human SOSB1 AA range: 70-120 |
| Immunogen Region | 70-120 |
| Specificity | This antibody detects endogenous levels of human SOSB1 |
Additional Info
| Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. |
| Protein Name | Soss Complex Subunit B1Nucleic Acid-Binding Protein 2Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2bSensor Of Single-Strand Dna Complex Subunit B1Sensor Of Ssdna Subunit B1Soss-B1Single-Stranded Dna-Binding Protein 1Hssb1 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusLocalizes To Nuclear Foci Following Dna DamageFoci Formation Is Not Cell-Cycle DependentPartial Colocalization With Rad51 After Ionizing Radiation Treatment |
| Alternative Antibody Names | Anti-Soss Complex Subunit B1 antibodyAnti-Nucleic Acid-Binding Protein 2 antibodyAnti-Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2b antibodyAnti-Sensor Of Single-Strand Dna Complex Subunit B1 antibodyAnti-Sensor Of Ssdna Subunit B1 antibodyAnti-Soss-B1 antibodyAnti-Single-Stranded Dna-Binding Protein 1 antibodyAnti-Hssb1 antibodyAnti-NABP2 antibodyAnti-OBFC2B antibodyAnti-SSB1 antibodyAnti-LP3587 antibody |
Information sourced from Uniprot.org